Sweet and Spicy Grilled Salmon Go sweet and spicy. Combine 1 1/2 teaspoons brown sugar, 1 teaspoon chili powder, and a pinch each of kosher salt and black pepper in a small bowl. Rub over a 4-ounce salmon fillet. Grill for 6 to 8 minutes, flipping halfway through. The sugar in this rub caramelizes during cooking, giving the fish a rich flavor.